Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
Unrelated cord blood transplantation for children with high risk myelodysplastic syndromes.
Allogeneic stem cells transplantation represents the only curative therapeutic option for patient with MDS; search of unrelated donor, including umbilical cord blood, should be mandatory for MDS who lack an HLA-identical sibling, particularly in pediatric patients who have longer life expectancy than adults. We report the results of unrelated CBT in 5 children with high risk MDS transplanted at...
متن کاملUnrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome.
We report the results of unrelated cord blood transplantation (CBT) for 13 adult patients with advanced myelodysplastic syndrome (MDS). The median age was 40 years, the median weight was 51 kg, and the median number of infused nucleated cells was 2.43 x 107/kg. Twelve patients had myeloid reconstitution, and the median time to more than 0.5 x 109/L (5 x 108/L) absolute neutrophil count was 22.5...
متن کاملEngraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen.
Umbilical cord blood transplant recipients are exposed to an increased risk of graft failure, a complication leading to a higher rate of transplant-related mortality. The decision and timing to offer a second transplant after graft failure is challenging. With the aim of addressing this issue, we analyzed engraftment kinetics and outcomes of 1268 patients (73% children) with acute leukemia (64%...
متن کاملUnrelated umbilical cord blood transplantation in children and adults.
Umbilical cord blood (UCB) has recently been explored as an alternative haematopoietic stem cell (HSC) source for allogeneic immunotherapy in both adults and paediatric patients with haematological malignancies and marrow failure syndromes. The relative ease of procurement, tolerance of 1-2 antigen human-leukocyte antigen (HLA) mismatch and the lower than anticipated risk of severe graft-versus...
متن کاملLong-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS
Autologous cord blood transplantations are rarely applied in patients with hematologic as well as metastatic solid cancers since contamination of malignant clones is a concern. We report a case of therapy-related myelodysplasia after metastatic neuroblastoma who suffered from graft rejection and life-threatening infections after a myeloablative unrelated cord blood transplantation. The patient ...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2010
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2010.91